MUCINS AND MUCOIDS

Mucins and Pancreatic Cancer

Pancreatic cancer is characterized by an often dramatic outcome (five year survival < 5%) related to a late diagnosis and a lack of efficient therapy. Therefore, clinicians desperately need new biomarkers and new therapeutic tools to develop new efficient therapies. Mucins belong to an ever increasing family of O-glycoproteins. Secreted mucins are the main component of mucus protecting the epit...

Cystic fibrosis and mucins.

The physicochemical properties of two mucoids from bovine cervical mucin.

Membrane Mucins and Breast Cancer.

Cancer Control 613 Membrane mucins have been implicated in a number of carcinomas. The prototype MUC1 is overexpressed in most breast cancers and is the target for both diagnostic assays and immunotherapy. Two attributes of membrane mucins contribute to the interest in their expression in tumors. First, their rigid structures provide an antirecognition function that alters cell adhesiveness and...

Mucus, epithelial mucins and cytoprotection

Mucus, epithelial mucins and cytoprotection Epithelial mucins are widely accepted to play cytoprotective roles in the gastrointestinal tract. However, the number and nature of these complex glycoproteins is only just beginning to emerge. We aimed to identify the mucins in biopsies from human small intestine and colon in health and disease, by raising specific antisera and studying the biosynthe...